A Key Detail in Some People’s Childhoods May Lead to Vaccine Resistance, Study

Most people welcomed the opportunity to get vaccinated against COVID-19, yet a non-trivial minority did not. Vaccine-resistant people tend to hold strong views and assertively reject conventional medical or public health recommendations. This is puzzling to many, and the issue has become a flashpoint in several countries.

It has resulted in strained relationships, even within families, and at a macro-level has threatened social cohesion, such as during the month-long protest on parliament grounds in Wellington, New Zealand.

This raises the question: where do these strong, often visceral anti-vaccination sentiments spring from? As lifecourse researchers we know that many adult attitudes, traits and behaviors have their roots in childhood. This insight prompted us to enquire about vaccine resistance among members of the long-running Dunedin Study, which marks 50 years this month.

Specifically, we surveyed study members about their vaccination intentions between April and July 2021, just prior to the national vaccine roll out which began in New Zealand in August 2021. Our findings support the idea that anti-vaccination views stem from childhood experiences.

The Dunedin Study, which has followed a 1972-73 birth cohort, has amassed a wealth of information on many aspects of the lives of its 1037 participants, including their physical health and personal experiences as well as long-standing values, motives, lifestyles, information-processing capacities and emotional tendencies, going right back to childhood.

Almost 90 percent of the Dunedin Study members responded to our 2021 survey about vaccination intent. We found 13 percent of our cohort did not plan to be vaccinated (with similar numbers of men and women).

When we compared the early life histories of those who were vaccine resistant to those who were not we found many vaccine-resistant adults had histories of adverse experiences during childhood, including abuse, maltreatment, deprivation or neglect, or having an alcoholic parent.

These experiences would have made their childhood unpredictable and contributed to a lifelong legacy of mistrust in authorities, as well as seeding the belief that “when the proverbial hits the fan you’re on your own”. Our findings are summarized in this figure.

(Dunedin Study, CC BY-ND)

Personality tests at age 18 showed people in the vaccine-resistant group were vulnerable to frequent extreme emotions of fear and anger. They tended to shut down mentally when under stress.

They also felt fatalistic about health matters, reporting at age 15 on a scale called “health locus of control” that there is nothing people can do to improve their health. As teens they often misinterpreted situations by unnecessarily jumping to the conclusion they were being threatened.

The resistant group also described themselves as non-conformists who valued personal freedom and self-reliance over following social norms. As they grew older, many experienced mental health problems characterized by apathy, faulty decision-making and susceptibility to conspiracy theories.

Negative emotions combine with cognitive difficulties

To compound matters further, some vaccine-resistant study members had cognitive difficulties since childhood, along with their early-life adversities and emotional vulnerabilities. They had been poor readers in high school and scored low on the study’s tests of verbal comprehension and processing speed. These tests measure the amount of effort and time a person requires to decode incoming information.

Such longstanding cognitive difficulties would certainly make it difficult for anyone to comprehend complicated health information under the calmest of conditions. But when comprehension difficulties combine with the extreme negative emotions more common among vaccine-resistant people, this can lead to vaccination decisions that seem inexplicable to health professionals.

Today, New Zealand has achieved a very high vaccination rate (95 percent of those eligible above the age of 12), which is approximately 10 percent higher than in England, Wales, Scotland or Ireland and 20 percent higher than in the US.

More starkly, the New Zealand death rate per million population is currently 71. This compares favorably to other democracies such as the US with 2,949 deaths per million (40 times New Zealand’s rate), UK at 2,423 per million (34 times) and Canada at 991 per million (14 times).

How to overcome vaccine resistance

How then do we reconcile our finding that 13 percent of our cohort were vaccine resistant and the national vaccination rate now sits at 95 percent? There are a number of factors that helped drive the rate this high.

They include:

• Good leadership and clear communication from both the prime minster and director-general of health

• leveraging initial fear about the arrival of new variants, Delta and Omicron

• widespread implementation of vaccine mandates and border closure, both of which have become increasingly controversial

• the…