Prisco’s Week 12 NFL picks: Cowboys, Bills blow out opponents on Thanksgiving;

It finally happened. I had a good week in all three areas of picking games. 

I went 4-2 with my best bets as part of the Pick Six podcast, 11-3 straight up and 7-5-2 against the spread in my CBSSports.com expert picks. 

That raises my best bet record to 38-25-2, which I am glad about. The straight-up record is now 95-69 and the ATS record is 74-82-8. The last one needs to get back up over .500, so that’s the goal for the next few weeks.

Let’s hope the holiday week is good to me, starting with a sweep on Thanksgiving in games that feature teams with some impressive records.

Thursday, 12:30 p.m. ET (CBS, Paramount+)

Featured Game | Detroit Lions vs. Buffalo Bills

This has the makings of a game with a lot of offense. Both teams can score, but the Bills can really score. They will put up a big number here as Josh Allen wins a second straight game in Detroit after beating the Browns last week in the same building. The track is fast and the Bills can fly. The Lions won’t keep up. 

Pick: Bills 40, Lions 23

Thursday, 4:30 p.m. ET (Fox, FuboTV)

Featured Game | Dallas Cowboys vs. New York Giants

The Giants are coming off of a horrible showing at home against the Lions, which means they might have been looking ahead to this one. The Cowboys righted things in their blowout victory over the Vikings. The defense dominated, and it will dominate here as well. The Giants are too limited on offense. 

Pick: Cowboys 31, Giants 14

Thursday, 8:20 p.m. ET (NBC, FuboTV)

Featured Game | Minnesota Vikings vs. New England Patriots

The Vikings were embarrassed Sunday at home, getting blown out by the Cowboys. They will bounce back and play better here. The New England offense is struggling, but the defense is playing well. Even so, I think the Vikings will respond on offense in this one to win it. The Patriots offense is bad. 

Pick: Vikings 24, Patriots 14

Sunday, 1 p.m. ET (Fox, FuboTV)

Featured Game | Carolina Panthers vs. Denver Broncos

This is the dog game of the week with two horrible offenses. First one to 10 wins? Denver has the better defense, but at home I think the Panthers will find a way to win this one. Denver continues to struggle. 

Pick: Panthers 17, Broncos 13

Sunday, 1 p.m. ET (Fox, FuboTV)

Featured Game | Cleveland Browns vs. Tampa Bay Buccaneers

The Bucs come off the bye in first place and seemingly ready to get their season going like they expected. They are getting healthier, and that will matter down the stretch, starting here in this one. The Browns are bad on defense, so look for Tom Brady to have a solid day. The Browns running game is limited. Bucs take it. 

Pick: Bucs 30, Browns 17

Sunday, 1 p.m. ET (CBS, Paramount+)

Featured Game | Jacksonville Jaguars vs. Baltimore Ravens

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