Prisco’s NFL Week 2 picks: Saints knock off Tom Brady again, Giants go to 2-0

The first week of the NFL season is always so unpredictable. So I will be happy with my first week of picks after seeing what transpired in Week 1. 

I went 7-8-1 straight up, which stinks. I went 8-8 against the spread, which is so-so. But the great news is that I went 5-1 with my best bets as part of the Pick Six Podcast. And if not for me adding the Jacksonville Jaguars late, it would have been a clean sweep. Even that looked good for a while, too.

So let’s get back at it in what I call get-even week in the NFL. Teams that looked bad in Week 1 probably won’t look that way in the second week, while the reverse is likely true for some of the winners. It won’t always play out that way, but I think it will this week in a lot of the games.

Time to get the straight-up record back on track but, most of all, let’s stay hot with the best bets.

Thursday, 8:20 p.m. ET (Amazon Prime)

Featured Game | Kansas City Chiefs vs. Los Angeles Chargers

This is the game of the week with Justin Herbert against Patrick Mahomes. That is a treat anytime they meet, and Arrowhead will be rocking on Thursday night. The Chiefs rolled against the Cardinals with Mahomes lighting things up. But the Chargers can rush the passer with Khalil Mack and Joey Bosa. Look for a high-scoring game with the Chiefs winning a close one. 

Pick: Chiefs 31, Chargers 30

Sunday, 1 p.m. ET (CBS, Paramount+)

Featured Game | Baltimore Ravens vs. Miami Dolphins

The Dolphins and Ravens both won in impressive fashion last week, but now Miami goes on the road for the first time. The Dolphins dominated the Ravens last year at home, but this will be different. The Ravens and Lamar Jackson get the best of the Dolphins. 

Pick: Ravens 27, Dolphins 20

Sunday, 1 p.m. ET (CBS, Paramount+)

Featured Game | Cleveland Browns vs. New York Jets

The Browns will be facing a familiar quarterback this week in Joe Flacco. He wasn’t good last week in the Jets’ loss to the Ravens. The Browns got a close win against Carolina last week, but they are home in this one and Jacoby Brissett will play better in his second start for the Browns. They go to 2-0. 

Pick: Browns 24, Jets 13

Sunday, 1 p.m. ET (Fox, FuboTV)

Featured Game | Detroit Lions vs. Washington Commanders

The Commanders are coming off a home victory over the Jaguars where Carson Wentz drove them to the game-winning score late. The Lions looked good on offense against the Eagles, but the defense was terrible. This could end up being a shootout. Washington is the better team, and I think that will show up. Commanders take it. 

Pick: Commanders 31, Lions 27

Sunday, 1 p.m. ET (CBS, Paramount+)

Featured Game | Jacksonville Jaguars vs. Indianapolis Colts

The Colts haven’t won in Jacksonville since 2014 and lost there last year in the final week to cost them a playoff spot. They are also playing consecutive road games, while Jacksonville is playing its home opener. That’s a big edge to the Jaguars. The Colts rallied to tie the Texans last week, but this time around they won’t rally to win. The Jaguars will get their first victory. 

Pick: Jaguars 26, Colts 23

Sunday, 1 p.m. ET (Fox, FuboTV)